|
|
|
Technology Immune System |
Technology :: PublicationsGeneral | Hepatitis | Influenza | Allergy/ Asthma | IRS / TLR Inhibitors | ISS / TLR | Cancer GeneralDebbie Higgins, Jason D Marshal, Paula Traquina, Gary Van Nest and Brian Livingston: Immunostimulatory DNA as a Vaccine Adjuvant. The Expert Review of Vaccines, October 2007 Livingston BD, Higgins D, Van Nest G Evolving strategies for the prevention of influenza infection: potential for multistrain targeting. BioDrugs Volume 20, Number 6, 2006, pp. 335-340(6). Teleshova, N., J. Kenney, J. Jones, J. Marshall, G. Van Nest, J. Dufour, R. Bohm, J.D. Lifson, A. Gettie, and M. Pope. CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells. J. Immunol., 2004. 173(3):1647-1657. Pyles, R.B., D. Higgins, C. Chalk, A. Zalar, J. Eiden, C. Brown, G. Van Nest, and L.R. Stanberry. Use of Immunostimulatory Sequence-Containing Oligonucleotides as Topical Therapy for Genital Herpes Simplex Virus Type 2 Infection. J. of Virology, 2002; 76: 11387-11396. View in PDF format. Horner, A.A., A. Ronaghy, P.M. Cheng, M.D. Nguyen, H.J. Cho, D. Broide, and E. Raz. Immunostimulatory DNA Is a Potent Mucosal Adjuvant. Cell. Immunol. 1998; 190: 77-82. Roman, M., E. Martin-Orozco, J.S. Goodman, M.D. Nguyen, Y. Sato, A. Ronaghy, R.S. Kornbluth, D.D. Richman, D.A. Carson, and E. Raz. Immunostimulatory DNA Sequences Function as T helper-1-promoting Adjuvants. Nature Medicine. 1997; 3: 849-854. HepatitisScott A. Halperin, Simon Dobson, Shelly McNeil, Joanne M. Langley, Bruce Smith, Robyn McCall-Sani, Dan Levitt, Gary Van Nest, Daniel Gennevois, Joseph J. Eiden. Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults. Vaccine 24 (2006) 20-26. Halperin, S.A., G. Van Nest, B. Smith, S. Abtahi, H. Whiley, and J.J. Eiden. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine. 2003; 21: 2461-2467. InfluenzaLivingston BD, Higgins D, Van Nest G Evolving strategies for the prevention of influenza infection: potential for multistrain targeting. BioDrugs Volume 20, Number 6, 2006, pp. 335-340(6). Allergy / AsthmaJohn D. Campbell, Yan Cho, Martyn L. Foster, Holger Kanzler, Melissa A. Kachura, Jeremy A. Lum, Marianne J. Ratcliffe, Atul Sathe, Andrew J. Leishman, Ash Bahl, Mark McHale, Robert L. Coffman and Edith M. Hessel: CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans: J. Clin. Invest. doi:10.1172/JCI38294 Tomoko Hayashi, MD, PhD, Eyal Raz, MD. TLR9-Based Immunotherapy for Allergic Disease. The American Journal of Medicine, Vol 119, No 10, October 2006. Higgins, D., Rodriguez, R., Milley, R., Marshall, J., Abbate, C., dela Cruz, T., Patton, K., Walker, F., Chichester, K., Eiden, J., Tuck, S., Van Nest, G. Modulation of immunogenicity and allergenicity by controlling the number of immunostimulatory oligonucleotides linked to Amb a 1. J. Clin. Allergy and Clin. Immunol. Robert L. Coffman. Origins of the Th1-Th2 model: a personal perspective. Nat Immunol. 2006 Jun;7(6):539-41. Gail M Gauvreau, Edith M Hessel, Louis-Philippe Boulet, Robert L Coffman, and Paul M O'Byrne. Immunostimulatory Sequences Regulate Interferon-inducible Genes but not Allergic Airway Responses. Am. J. Respir. Crit. Care Med. 2006. Edith M. Hessel, Mabel Chu, Jennifer O. Lizcano, Bonnie Chang, Nancy Herman, Sariah A. Kell, Marsha Willis-Karp, and Robert L. Coffman. Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction. JEM published November 28, 2005, 10.1084/jem.20050631. View in PDF Format. Robert L. Coffman and Edith M. Hessel. Nonhuman primate models of asthma. J. Exp. Med., 2005, Vol. 201 (12):1875–1879. View in PDF Format. Simons, F.E., Y. Shikishima, G. Van Nest, J.J. Eiden, and K.T. HayGlass. Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J. Allergy Clin. Immunol., 2004. 113(6):1144-1151. Tulic, M.K., P.O. Fiset, P. Christodoulopoulos, P. Vaillancourt, M. Desrosiers, F. Lavigne, J. Eiden, and Q. Hamid. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J. Allergy Clin. Immunol., 2004. 113(2):235-241. Santeliz, J.V., G. Van Nest, P. Traquina, E. Larsen, and M. Wills-Karp. Amb a 1-linked CpG Oligodeoxynucleotides Reverse Established Airway Hyperresponsiveness in a Murine Model of Asthma. J. Allergy Clin. Immunol., 2002; 109: 455-462. Marshall, J.D., S. Abtahi, J.J. Eiden, S. Tuck, R. Milley, F. Haycock, M.J. Reid, A. Kagey-Sobotka, P.S. Creticos, L.M. Lichtenstein, and G. Van Nest. Immunostimulatory Sequence DNA Linked to the Amb a 1 Allergen Promotes Th1 Cytokine Expression While Downregulating Th2 Cytokine Expression in PBMCs from Human Patients with Ragweed Allergy. J. Allergy Clin. Immunol. 2001; 108: 191-197. Van Uden, J. and E. Raz. Immunostimulatory DNA and Applications to Allergic Disease. J. Allergy Clin. Immunol. 1999; 104: 902-910. Spiegelberg, H.L., E.M. Orozco, M. Roman, and E. Raz. DNA Immunization: A Novel Approach to Allergen-specific Immunotherapy. Allergy. 1997; 52: 964-970. IRS / TLR InhibitorsGuiducci C, Coffman RL, Barrat FJ (Dynavax Technologies Corporation, Berkeley, CA USA). Signalling pathways leading to IFN-a production in human PDC and the possible use of agonists or antagonists of TLR-7 and TLR-9 in clinical indications (Review). J Intern Med 2008; 265:43-57. Xiaoping Qing, Milena Pitashny, David B. Thomas, Franck J. Barrat, Mark P. Hogarth, Chaim Putterman. Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: Involvement of HMGB1 in anti-DNA antibody-induced renal injury. Immunology Letters, 2008, 121: 61–73; Frank J. Barrat and Robert L. Coffman. Development of TLR inhibitors for the treatment of autoimmune diseases. July 2008 Immunological Reviews Vol. 223: 271-283. Franck J. Barrat, Thea Meeker, Jean H. Chan, Cristiana Guiducci and Robert L. Coffman. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur. J. Immunol., 2007 Nov 22; Denny M.F., Thacker S., Mehta H., Somers E.C., Dodick T., Barrat F.J., McCune W.J. and Kaplan M.J.. Interferon-{alpha} promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood, 2007. 110:2907-2915. Marshall JD, Heeke DS, Gesner ML, Livingston B, Van Nest G. Negative regulation of TLR9-mediated IFN-{alpha} induction by a small-molecule, synthetic TLR7 ligand. Journal of Leukocyte Biology Volume 82, September 2007. View PDF File Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nature Medicine Vol 13, No 5, May 2007. Franck J. Barrat, Thea Meeker, Josh Gregorio, Jean H. Chan, Satoshi Uematsu, Shizuo Akira, Bonnie Chang, Omar Duramad, and Robert L. Coffman. Nucelic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med., 2005, Vol. 202 (8): 1131-1139. View in PDF Format. Omar Duramad, Karen L. Fearon, Bonnie Chang, Jean H. Chan, Josh Gregorio, Robert L. Coffman, and Franck J. Barrat. Inhibitors of TLR-9 Act on Multiple Cell Subsets in Mouse and Man In Vitro and Prevent Death In Vivo from Systemic Inflammation. J. Immunol., 2005; 174: 5193–5200. View in PDF Format. ISS / TLRJohn D. Campbell, Yan Cho, Martyn L. Foster, Holger Kanzler, Melissa A. Kachura, Jeremy A. Lum, Marianne J. Ratcliffe, Atul Sathe, Andrew J. Leishman, Ash Bahl, Mark McHale, Robert L. Coffman and Edith M. Hessel: CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans: J. Clin. Invest. doi:10.1172/JCI38294 Cristiana Guiducci, Cristina Ghirelli, Marie-Annick Marloie-Provost, Tracy Matray, Robert L. Coffman, Yong-Jun Liu, Franck J. Barrat, and Vassili Soumelis. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med. 2008 Feb 18;205(2):315-22 View PDF File. Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nature Medicine Vol 13, No 5, May 2007. Felix Yarovinsky, Holger Kanzler, Sara Hieny, Robert L. Coffman, and Alan Sher. Toll-like Receptor Recognition Regulates Immunodominance in an Antimicrobial CD4+ T Cell Response. Immunity 25, 665-664, October 2006. Cristiana Guiducci, Gary Ott, Jean H. Chan, Emily Damon, Carlo Calacsan, Tracy Matray, Kyung-Dall Lee, Robert L. Coffman and Franck J. Barrat. Properties Regulating the Nature of the Plasmacytoid Dendritic Cell Response to TLR9 Activation. J Exp Med. 2006 Aug 7;203(8):1999-2008 . View in PDF Format. Jason D. Marshall, Darren S. Heeke, Christi Abbate, Priscilla Yee and Gary Van Nest. Induction of interferon-gamma from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid-dendritic-cell-produced interferon-alpha and tumor necrosis factor-alpha. Immunol., 2005, 117: 38-46. Kun Yang, Anne Puel, Shenying Zhang, Céline Eidenschenk, Cheng-Lung Ku, Armanda Casrouge, Capucine Picard, Horst von Bernuth, Brigitte Senechal, Sabine Plancoulaine, Sami Al-Hajjar, Abdulaziz Al-Ghonaium, László Maródi, Donald Davidson, David Speert, Chaim Roifman, Ben-Zion Garty, Adrian Ozinsky, Franck J. Barrat, Robert L. Coffman, Richard L. Miller, Xiaoxia Li, Pierre Lebon, Carlos Rodriguez-Gallego, Helen Chapel, Frédéric Geissmann, Emmanuelle Jouanguy, and Jean-Laurent Casanova. Human TLR-7-, -8-, and -9-Mediated Induction of IFN-alpha/beta and -lambda is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses. Immunity, 2005. Vol. 23, 465-478. Marshall, J.D., K.L. Fearon, D. Higgins, E.M. Hessel, H. Kanzler, C. Abbate, P. Yee, J. Gregorio, T.D. Cruz, J.O. Lizcano, A. Zolotorev, H.M. McClure, K.M. Brasky, K.K. Murthy, R.L. Coffman, and G.V. Nest. Superior Activity of the Type C Class of ISS In Vitro and In Vivo Across Multiple Species. DNA Cell Biol., 2005. 24(2):63-72. Marshall, J.D., D. Higgins, C. Abbate, P. Yee, G. Teshima, G. Ott, T. Dela Cruz, D. Passmore, K.L. Fearon, S. Tuck, and G. Van Nest. Polymyxin B enhances ISS-mediated immune responses across multiple species. Cell Immunol., 2004. 229(2):93-105. Duramad, O., K.L. Fearon, J.H. Chan, H. Kanzler, J.D. Marshall, R.L. Coffman, and F.J. Barrat. IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood, 2003. 102(13):4487-4492. Marshall, J.D., E.M. Hessel, J. Gregorio, C. Abbate, P. Yee, M. Chu, G.V. Nest, R.L. Coffman, and K.L. Fearon. Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells. Nucl. Acids Res., 2003. 31(17):5122-5133. View in PDF format. Fearon, K., J.D. Marshall, C. Abbate, S. Subramanian, P. Yee, J. Gregorio, G. Teshima, G. Ott, S. Tuck, G. Van Nest, and R.L. Coffman. A minimal human immunostimulatory CpG motif that potently induces IFN-gamma and IFN-alpha production. Eur. J. Immunol., 2003; 33: 2114-2122. Marshall, J.D., K. Fearon, C. Abbate, S. Subramanian, P. Yee, J. Gregorio, R.L. Coffman, and G. Van Nest. Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J. Leukoc. Biol., 2003. 73(6):781-792. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M.D. Nguyen, G.J. Silverman, M. Lotz, D.A. Carson, and E. Raz. Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization. Science. 1996; 273: 352-354. CancerFriedberg, J.W., H. Kim, M. McCauley, E.M. Hessel, P. Sims, D.C. Fisher, L.M. Nadler, R.L. Coffman, and A.S. Freedman. Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkins lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity. Blood, 2005. 105(2):489-495. Cho, H.J., K. Takabayashi, P.M. Cheng, M.D. Nguyen, M. Corr, S. Tuck, and E. Raz. Immunostimulatory DNA-based Vaccines Induce Cytotoxic Lymphocyte Activity by a T Helper Cell-independent Mechanism. Nat. Biotechnol. 2000; 18: 509-514. |
|
 |